Active Pharmaceutical Ingredients
Product Introduction
Omeprazole is a proton pump inhibitor used to treat peptic ulcers, gastroesophageal reflux disease (GERD) and other diseases. It can specifically act on the site of the proton pump in gastric parietal cells and convert it into subunits. The active form of sulfenamide is then irreversibly combined with the sulfhydryl group of the proton pump through a disulfide bond to form a complex of sulfenamide and proton pump (H+-K+-ATPase), thereby inhibiting the activity of the enzyme and causing H+ cannot be transported into the gastric cavity, blocking the final step of chemicalbook gastric acid secretion, which can greatly reduce the amount of gastric acid in gastric juice. Therefore, this product has a strong and long-lasting inhibitory effect on gastric acid secretion caused by various reasons (such as basal gastric acid secretion and gastric acid secretion caused by histamine, pentagastrin and vagus nerve stimulation, including H2 receptor blockers that cannot Inhibition of gastric acid secretion by dibutyl cyclic adenosine monophosphate). This is related to the irreversible inhibitory effect of this product on proton pumps. Only after a new proton pump is formed can the acid secretion effect be restored.
Salidroside Process Workflow
1)2,3,5-trimethylpyridine-N-oxide (2) 2,3,5-trimethylpyridine and phosphotungstic acid are added to the three-necked flask, stir and heat to 90°C, and slowly add dropwise H2O2, complete the dripping in about 2 hours, and keep warm for reaction. Add a small amount of hydrazine hydrate to decompose excess H2O2, extract with dichloromethane, dry with anhydrous magnesium sulfate and filter, and concentrate the filtrate to obtain white solid 2.
2) 2,3,5-trimethyl-4-nitropyridine-N - Slowly add concentrated sulfuric acid to the oxide (3) 2, stir and heat to 90°C, add dropwise the mixed acid composed of concentrated sulfuric acid and nitric acid, complete the dripping in 1.5 hours, and keep warm for reaction. Cool to 0°C and extract with ethyl acetate. Pour the ethyl acetate phase into ice water, add 5% sodium carbonate solution to adjust to neutrality, let stand and separate the layers, dry the organic phase with anhydrous magnesium sulfate, filter, and concentrate the filtrate to dryness to obtain a light yellow solid 3.
3) 2 -Hydroxymethyl-3,5-dimethyl-4-nitropyridine (4)3 and glacial acetic acid were stirred and heated to 90°C. Acetic anhydride was slowly added dropwise for about 50 minutes. The reaction was continued at the same temperature for 2 hours. Recover the solvent under reduced pressure, cool the residue to 60°C, add 15% hydrochloric acid, insulate and react for 2 hours, add 10% sodium carbonate solution to adjust to pH 8, extract the aqueous layer with dichloromethane, dry with anhydrous sodium sulfate, filter, and concentrate the filtrate , to obtain white powder 4.
4) 2-Chloromethyl-3,5-dimethyl-4-nitropyridine hydrochloride (5) 4 and chloro Chemical book were slowly added dropwise with thionyl chloride at room temperature, and the dripping was completed. The temperature was raised to 50°C and the reaction was stirred for 2 hours. The excess thionyl chloride and chloroform were recovered under reduced pressure. Toluene was added, cooled to 0°C, filtered with suction, and the filter cake was washed with a small amount of toluene (10ml) and dried to obtain white powder 5.
5) 5-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylthio]-1H-benzimidazole (6)5 (20g, 0.084mol) , 2-mercapto-5-methoxybenzimidazole (15.2g, 0.084mol) was added to a 250ml three-neck flask, add anhydrous methanol (100ml), stir and heat to reflux, slowly add 28% sodium methoxide, and complete the addition. Continue the reflux reaction for 4 hours, recover the solvent, add water to the residue, add hydrochloric acid to adjust the pH to 8~9, extract with dichloromethane, dry with anhydrous sodium sulfate and filter, the filtrate is concentrated, add acetone to the residue, freeze and suction filter, to obtain White solid 6.
6) Omeprazole (1) 6 and dichloromethane are cooled to below -20°C with dry ice, and a mixture of m-chloroperoxybenzoic acid and dichloromethane is slowly added dropwise, and the dripping is completed in about 1 hour, - React at 25~-20°C for 2 hours, add sodium carbonate aqueous solution, stir for 0.5 hours, leave to separate, wash the organic layer with water, dry over anhydrous magnesium sulfate, filter, concentrate the filtrate, add acetonitrile to the remainder, and leave in the refrigerator to crystallize , suction filtration to obtain white powdery crystal
Product Function
Drugs that inhibit gastric acid secretion. Omeprazole is a proton pump inhibitor that can effectively inhibit gastric acid secretion. The trade names on the market include omeprazole, omeprazole, fenamiprazole, losec, methoxysulfazole, and wobi. Azole and wortimiprazole are acid-suppressing drugs. Common acid-suppressing drugs also include pantoprazole, rabeprazole, and esomeprazole. Their mechanism of action is to selectively act on gastric mucosal parietal cells. , inhibits the activity of H+, K+-ATPase on the secretory microtubules composed of the apical membrane of gastric parietal cells and the tubular vesicles in the cytoplasm, thereby effectively chemically inhibiting the secretion of gastric acid. It has a rapid onset of action and is suitable for the treatment of gastric ulcers, Duodenal ulcer, reflux esophagitis, and gastrinoma (Zerollis-Ellison syndrome). However, it should be noted that excessive use of acid-suppressing drugs such as omeprazole can reduce the concentration of gastric acid and weaken the acidity. Then the bacteria entering the stomach may not be killed and enter the intestines, doubling the risk of intestinal infection bacteria. It may cause diarrhea. Reduced gastric acid affects digestion, which in turn affects the intestinal absorption of calcium, iron and other trace elements and vitamins, leading to calcium deficiency in the body and prone to fractures.
Product Application
People use citicoline for age-related decline in memory and thinking, glaucoma, stroke, Alzheimer disease, bipolar disorder, depression, and many other conditions, but there is no good scientific research to support most of these uses.
What Can We Do?
1.Used for gastric and duodenal ulcers, stress ulcers, etc.
2.Used for reflux esophagitis and gastrinoma.
3.This injection can also be used for: ① Gastrointestinal bleeding, such as peptic ulcer bleeding, anastomotic ulcer bleeding, etc., and prevention of upper gastrointestinal bleeding caused by severe diseases (such as cerebral hemorrhage, severe trauma, etc.) and after gastric surgery. ② Acute gastric mucosal Chemicalbook injury complicated by stress or caused by non-steroidal anti-inflammatory drugs. ③After general anesthesia or major surgery and comatose patients, to prevent acid reflux and aspiration pneumonia.
4.Combined with amoxicillin and clarithromycin, or combined with metronidazole and clarithromycin, it can effectively kill Helicobacter pylori (Hp).
Product Data Sheets
Packing & Shipping
What We Can Do?
