Active Pharmaceutical Ingredients

Flavoring Agents Neohesperidin Natural Made Diabetic Food High Sweetness

Flavoring Agents Neohesperidin Natural Made Diabetic Food High Sweetness

Product Name: Neohesperidin

CAS number: 13241-33-3

Molecular formula: C28H34O15

Molecular weight: 610.56

EINECS number: 236-216-9

Melting point: 239-243°C

Boiling point: 933.7±65.0°C(Predicted)

Density: 1.65±0.1g/cm3(Predicted)

Vapor pressure: 0Paat20℃

Storage conditions: Sealedindry, 2-8°C

Solubility: DMSO (trace), pyridine (trace Chemicalbook)

Acidity coefficient (pKa): 7.14±0.40 (Predicted)

Color: white to off-white

Water solubility: 3.98mg/Lat20℃

BRN: 74945

InChIKey: ARGKVCXINMKCAZ-RTFRIYMLSA-N

LogP: -0.69at20℃

Neohesperidin is a new natural nutritional sweetener extracted from Citrus aurantium. Its hydrogenated neohesperidin dihydrochalcone is 1500-2000 times sweeter than sucrose and is widely used in Sweeteners (flavoring agents) for juices, fruit wines, beverages, cakes and pharmaceutical formulations, especially suitable as food for diabetic patients.

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Product Function

Neohesperidin, a flavonoid glycoside found in citrus fruits, is an antioxidant. In the 1,1-diphenyl-2-picryldydrazyl (DPPH) free radical scavenging test, Neohesperidin acted as an antioxidant with an IC50 of 22.31 μg/ml. Neohesperidin (50 mg/kg) significantly inhibited HCl/ethanol Chemicalbook-induced gastric damage and increased mucus content. In pyloric ligated rats, neohesperidin (50 mg/kg) significantly reduced the amount of gastric secretions and gastric acid production, and increased the pH value. In addition, Neohesperidin inhibited the growth of Caco-2, CEM/ADR5000 and CCRF-CEM leukemia cells with IC50 values of 0.17, 0.17 and 0.12mM respectively.

Product Application

Widely used in sweeteners (flavoring agents) for juices, fruit wines, beverages, cakes and pharmaceutical formulations, and in foods for diabetic patients.