Product Introduction
This product is gray yellow to yellow powder or crystalline powder, odorless.Diosamine (Diosmin), an organic compound with the chemical formula C28H32O15, enhances intravenous tonic drugs and vascular protectors. For the venous system, either by lengthening. Adrinephrine acts on the venous wall to cause contraction, thus enhancing the venous tension; for the microcirculation system, it can reduce the capillary permeability and enhance its resistance; for the lymphatic system, it can increase the lymphatic drainage speed and lymphatic vessel contraction, improve lymphatic reflux and reduce edema. This product is gray yellow to yellow powder or crystalline powder, odorless.
This product was dissolved in dimethylsulfoxide, insoluble in water, methanol or ethanol, extremely micro-dissolved in 0.1 mol/L sodium hydroxide solution, and almost insoluble in 0.1 mol/L hydrochloric acid solution. Diosine, also known as gerinside, mainly exists in the roots of two needles and the fruit of Buddha's hand, the peel of lemon. For 7-with double pond base flavonoids, isolated by Scrophularis nodosa in 1925, was used as a drug in 1969, eventually developed by the French company, listed in 1987, trade name love pulse Lang, is a new work of all kinds of hemorrhoids and chronic venous insufficiency, pure particulate flavonoids.
Diosmine treats hemorrhoids and venous insufficiency by increasing venous tension, promoting lymphatic reflux, and promoting microcirculation. Treatment of heavy legs, pain, acid distension discomfort in the morning and acute hemorrhoids related symptoms.
In recent years, some new effects have been more and more attention, researchers found that in anti-tumor, treatment of diabetes, anti-inflammatory and other face show good activity. Diosmine is used more and more in clinical practice and has achieved good clinical results.
Product Function
1.Enhance the venous tension.
Diosmine enhances the venous wall tension, even at high temperature. It causes a stronger contraction effect of the veins than other drugs such as rutin, and can still enhance the venous tension when the body is acidosis. Diosmine has a specific affinity for the veins without affecting the arterial system.
2.Improve the microcirculation.
To osine can significantly reduce the adhesion of white blood cells and vascular endothelial cells, migration, disintegration release of inflammatory substances, such as histamine, slow kinin, complement, leukotriene, prostaglandin and too many free radicals, etc., thus reducing capillary permeability and enhance its tension, to osine also has lower blood viscosity, enhance the function of red blood cell flow rate, thus reduce the microcirculation stasis.
3.To promote lymphatic reflux.
Diosamine increases the rate of lymphatic drainage and lymphatic vessel contraction, thus accelerating the reflux of intertissue fluid, improving lymphatic reflux, and reducing edema.
Product Application
1.Capillary vascular protectant.
Its preparation is used to treat various symptoms related to venous lymphatic insufficiency (heavy legs, pain, acid swelling and discomfort in the morning). Treatment of the various symptoms associated with acute hemorrhoid attacks.
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Product Data Sheets
Analysis | Description | Result |
Appearance | Greyish-yellow or light yellow, hygroscopic powder | Complies |
Solubility | Practically insoluble in water, soluble in dimethyl sulfoxide, practically insoluble in ethanol (96%), it dissolves in dilute solution of alkali hydroxides | Complies |
Identification | A) IR: Complies diosmin CRS | Complies |
B) HPLC: Complies to the reference solution | ||
Iodine | ≤0.1% | Complies |
Related Substances | ||
Impurity A(Acetoisovanillone) | ≤0.5% | 0.0003 |
Impurity B(Hesperidin) | ≤4.0% | 0.0086 |
Impurity C(Isorhoifolin) | ≤3.0% | 0.026 |
Impurity D(6-iododiosmin) | ≤0.6% | 0.0042 |
Impurity E (Linarin) | ≤3.0% | 0.0216 |
Impurity F(Diosmetin) | ≤2.0% | 0.0036 |
Unspecified Impurities(each) | ≤0.4% | 0.0035 |
Total Impurities | ≤8.5% | 0.0678 |
Heavy Metals | ≤20ppm | Complies |
Water | ≤6.0% | 0.0397 |
Sulphated Ash | ≤0.2% | 0.0007 |
Particle Size | NLT95% pass 80 mesh | Complies |
Assay(HPLC, Anhydrous substance) | 90.0%~102.0% | 0.9137 |
Residual Solvents | ||
Pyridine | ≤200ppm | 121ppm |
Total Plate Count | ≤1000cfu/g | 30cfu/g |
-Yeast & Mold | ≤100cfu/g | <10cfu/g |
-E.Coli | Negative/g | Negative/g |
-Salmonella | Negative/25g | Negative/25g |