Cosmetic Raw Material Ergothioneine Powder Ergothioneine CAS 497-30-3

Ergothioneine is a natural amino acid derived from plants and can be accumulated in animals. Research has proven that it has the effect of an antioxidant. It can effectively remove -OH, chelate divalent iron ions and copper ions, and prevent H2O2 -OH is generated under the action of iron ions or copper ions, which can also inhibit the copper ion-dependent oxidation of oxyhemoglobin. It can also inhibit the peroxidation of arachidonic acid after myoglobin (or hemoglobin) is mixed with H2O2. reaction. Ergothioneine can also powerfully scavenge hypochlorous acid, thus preventing the inactivation of α1-antiprotease. However, it cannot inhibit the peroxidation reaction of lipid particles in the presence of iron ions. Studies by AKanmu D and others have shown that a certain concentration of ergothioneine in the body can act as an antioxidant.

Ergothioneine is a powerful scavenger of hypochlorous acid (HOCl). Although many compounds can react with hypochlorous acid, few react as quickly as ergothioneine. a 1-Antiprotease inhibitors (API), such as elastase, are particularly sensitive to hypochlorous acid, and physiological concentrations of ergothioneine can very effectively protect API against the inactivation caused by hypochlorous acid. Neutrophils are the main source of hypochlorous acid in the body, and one of the functions of ergothioneine is to protect red blood cells from neutrophils that come from normally functioning or pathologically inflammatory sites.

Peroxynitrite is endogenously formed by the limited diffusion reaction of NO and superoxide. It is a strong oxidant related to the pathophysiology of inflammation, such as ischemia-reperfusion injury, atherosclerosis, acute pneumonia and sepsis. Ergothioneine can inhibit peroxynitrite anion-mediated amino acid oxidation, such as nitration of tyrosine, thereby providing feasibility for the treatment of inflammation.

Since the discovery of ergothioneine, many attempts have been made to elucidate its physiological functions, but none has been able to completely define its physiological functions. Brummel.m.c research found that ergothioneine may also have the following functions: transporting cations and catalyzing carbon dioxide carboxylation or decarboxylation reactions; regulating thyroid and anti-thyroid effects; regulating histamine or antihistamine effects; cholinergic function or Anti-parasympathetic physiological effects; can regulate the reactivity of other acyl carriers or act as an acid carrier itself. Epand R M et al also studied the effect of ergothioneine on diabetes.

It has strong antioxidant activity: scavenging reactive oxygen species, chelating divalent metal ions, activating antioxidant enzymes, inhibiting superoxide dismutase, inhibiting oxidation reactions of various heme proteins, etc. Due to these properties of ergothioneine, it has a wide range of uses and market prospects in the fields of medicine, food and beverages, functional foods, animal feed, cosmetics and biotechnology.

Research has shown that ergothioneine cannot be synthesized in animals, but it has been clearly shown that histidine, the sulfuratom, and the methyl groups of methionine can be synthesized (incorporate into) in plants and microorganisms. D. Yanasugondha and M.D. Appleman studied the catabolism of ergothioneine in microorganisms. They found that ergothioneine can be converted into trimethylamine and thiol imidazole acrylic acid; Heath [3] fed long-term rats containing [S After eating ergothioneine, it was found that ergothioneine with [S] label was distributed in bone marrow, red blood cells, liver, kidney and other parts. George Wolf and others first injected [α-S]ergothioneine into rats, and then studied the distribution of radioactive energy and its metabolites. It was proved that herzynine is the precursor (precursor) for the synthesis of ergothioneine.

As for ergothioneine, a substance with significant and unique biological functions, scholars from various countries have long conducted research on its application. Although it still needs to be further deepened, it has played a very inspiring role in its application in various fields. Ergothioneine has a wide range of uses and market prospects in the fields of organ transplantation, cell preservation, medicine, food and beverages, functional foods, animal feed, cosmetics and biotechnology.

Ergothioneine is a highly protective, non-toxic natural antioxidant that is not easily oxidized in water, allowing its concentration to reach mmol in some tissues and stimulating the cell's natural antioxidant defense system. . Among many antioxidants, ergothioneine is particularly unique because ergothioneine can chelate heavy metal ions and protect red blood cells in the body from free radical damage.

The amount and duration of preservation of existing tissue play a decisive role in the success of organ transplantation. The most commonly used antioxidant in preserving organ transplants is glutathione. When it is exposed to the environment, it is easily oxidized. Even in refrigerated or liquid environments, its antioxidant capacity is greatly reduced and it is toxic to cells. It also produces inflammation and induces hydrolysis of tissue proteins. Ergothioneine is like an antioxidant that is stable in aqueous solution and can also chelate heavy metal ions. In the field of organ protection, it can be used as a substitute for glutathione to better protect transplanted organs.

Ultraviolet UVA in the sun can penetrate into the dermis of human skin, affecting the growth of epidermal cells, causing surface cells to age and die, causing premature aging of the skin, while ultraviolet UVB can easily lead to the occurrence of skin cancer. Ergothioneine can minimize the formation of reactive oxygen species and protect cells from radiation damage. Therefore, ergothioneine can be added to some cosmetics as a skin protectant to develop outdoor skin care products and protective cosmetics.

In recent years, studies have found that ergothioneine plays a key role in eye protection. Therefore, many researchers hope to develop an ophthalmic product to promote the development of ophthalmic treatment surgeries. Ophthalmic surgeries are generally performed locally, and the water solubility and stability of ergothioneine provide the feasibility of such surgeries and have great application value.

Ergothioneine can be used in many fields due to its excellent properties. For example, it is used in the fields of medicine, food, health products, cosmetics, etc. In the field of medicine, it can be used to treat inflammation, etc., and can be made into tablets, capsules, oral preparations, etc.; in the field of health products, it can prevent the occurrence of cancer, etc., and can be made into functional foods, functional drinks and other products. In the field of cosmetics, it can be used to treat inflammation, etc. It is used for anti-aging and can be made into sunscreen and other products.

As people's awareness of health care increases, the excellent properties of ergothioneine as a natural antioxidant will slowly be widely recognized and applied.

1. Free samples can be provided upon your request.

2. Production capacity: 20 tons/month.

3. The factory covers an area of 7,000 square meters and has 4 Ph.D. technical engineer.

4. Transportation method: express, air transport, sea transport

5. Quality control: 3rd party laboratory testing by Eurofins, SGS, BV etc.

6. 24 hours and 7 days full time standing-by services.