Products
Product Introduction
The extract is extracted from the dry bark and leaves of the eucommia ulmoides (EucommiauimoidesOliv). The active ingredients are mainly lignin, cycloether mushrooms, phenylpropanoids and other mushroom compounds, as well as polysaccharides, flavonoids, phenols, etc. Chlorogenic acid is a phenylpropanoid compound produced by the mang Chemicalbook oxalate pathway during aerobic respiration. Chlorogenic acid is an important bioactive substance, which has the functions of antibacterial, antiviral, increasing white blood cells, liver and gallbladder protecting, anti-tumor, lowering blood pressure-lowering, lowering blood lipid, removing free radicals and excitatory central nervous system. It is widely used, mainly used in medicine, daily chemicals and food and other industries.
Plant source: Dumacinaceae. Deciduous trees, bark, leaves, fruit after the broken silver white silk. The leaves are alternate, ovate-oval and serrated. Flowers are dioecious, with open front leaves, no peripals, flattened wings and long ellipses. Flowering period from March to May, and fruit period from July to September. Strong adaptability, cold resistance, like light, like humid climate and fertile soil. Chinese specialty, distribution from southwest to central. Origin: Chinese specialty, southwest to the central.
Plant source: Dumacinaceae. Deciduous trees, bark, leaves, fruit after the broken silver white silk. The leaves are alternate, ovate-oval and serrated. Flowers are dioecious, with open front leaves, no peripals, flattened wings and long ellipses. Flowering period from March to May, and fruit period from July to September. Strong adaptability, cold resistance, like light, like humid climate and fertile soil. Chinese specialty, distribution from southwest to central. Origin: Chinese specialty, southwest to the central.
Product Function
1)Antioxidant and scavenging effects of free radicals in the body.
Chlorogenic acid and its derivatives have stronger free radical scavenging effect than ascorbic acid, caffeic acid and tocopherol (vitamin E), which can effectively remove DPPH free radicals, hydroxyl free radicals and superoxide anion free radicals, and also inhibit the oxidation of low density lipoprotein. Chlorogenic acid plays an important role in effectively scavenging free radicals in the body, maintaining the normal structure and function of the body cells, preventing and delaying the occurrence of tumor mutation and aging.
2)Antibacterial and antiviral effects.
Chlorogenic acid and isochlorogenic acid can significantly inhibit and kill many pathogenic bacteria, such as Staphylococcus aureus, hemolytic streptococcus, dysentery coccus, typhoid bacillus, pneumococcus, etc. The antibacterial mechanism is related to the non-competitive inhibition of arylamine acetyltransferase Chemicalbook(NAT) in bacteria. Chlorogenic acid has obvious curative effect on acute throat inflammation and skin diseases, and is clinically used to treat acute bacterial infections. It has been reported that chlorogenic acid has anti-virus, hemostasis, increasing white blood cells, shortening blood coagulation and bleeding time.
3)Anti-mutational effect and anti-tumor effect.
Chlorogenic acid can inhibit the mutation induced by aflatoxin B and the mutation induced by subdigestive reaction, and can effectively reduce the mutation of bone marrow erythrocyte induced by gamma rays. Chlorogenic acid can reduce the utilization rate of carcinogens and its transportation in the liver through Chemicalbook to achieve the effect of cancer prevention and anticancer. Chlorogenic acid has a significant inhibitory effect on colorectal cancer, liver cancer and laryngeal cancer, and is considered to be an effective chemical protection agent for cancer.
4)On the cardiovascular protection effect.
Chlorogenic acid as a free radical scavenger and antioxidant has been proved by a large number of experiments, this biological activity of chlorogenic acid, can have a protective effect on the cardiovascular system. Chlorogenic acid Chemicalbook can protect vascular endothelial cells by scavenging free radicals and anti-lipid peroxidation, and then play a role in the prevention and treatment of atherosclerosis, thromboembolic diseases and hypertension.
5)Cholesterol-lowering effect.
The serum total cholesterol of the rats was significantly lower than that of the control group, indicating that Eucommia had an inhibitory effect on cholesterol absorption.
6)Effect of osteocyte proliferation.
The results showed that the water extract of Eutmoia ulmoia and different extracts of the water extract were cultured together with UMR106 osteoblast cells in vitro. The results showed that the water extract had the strongest effect on promoting the proliferation of Chemicalbook cells when cultured at 0.4 g/L for 48 hours, and the ethyl acetate extract and n-butanol extract had a certain effect on cell proliferation. The remaining water layer after extraction still retains the same effect of promoting cell proliferation as the original water layer.
7)Immunomodulation.
The leaf extract of Eucommia ulmoides can increase the spleen weight, the synthesis of RNA and protein in spleen tissue, increase the activity of natural killer cells in blood, and accelerate the proliferation of spleen lymphocytes, but has no obvious effect on spleen antibody forming cells in normal mice.
8)Sex hormones and sex-promoting hormone-like effects.
Eucommia ulmoides extract can increase the weight of prostate, ovary, testis, and levator muscle in animals.
Chlorogenic acid and its derivatives have stronger free radical scavenging effect than ascorbic acid, caffeic acid and tocopherol (vitamin E), which can effectively remove DPPH free radicals, hydroxyl free radicals and superoxide anion free radicals, and also inhibit the oxidation of low density lipoprotein. Chlorogenic acid plays an important role in effectively scavenging free radicals in the body, maintaining the normal structure and function of the body cells, preventing and delaying the occurrence of tumor mutation and aging.
2)Antibacterial and antiviral effects.
Chlorogenic acid and isochlorogenic acid can significantly inhibit and kill many pathogenic bacteria, such as Staphylococcus aureus, hemolytic streptococcus, dysentery coccus, typhoid bacillus, pneumococcus, etc. The antibacterial mechanism is related to the non-competitive inhibition of arylamine acetyltransferase Chemicalbook(NAT) in bacteria. Chlorogenic acid has obvious curative effect on acute throat inflammation and skin diseases, and is clinically used to treat acute bacterial infections. It has been reported that chlorogenic acid has anti-virus, hemostasis, increasing white blood cells, shortening blood coagulation and bleeding time.
3)Anti-mutational effect and anti-tumor effect.
Chlorogenic acid can inhibit the mutation induced by aflatoxin B and the mutation induced by subdigestive reaction, and can effectively reduce the mutation of bone marrow erythrocyte induced by gamma rays. Chlorogenic acid can reduce the utilization rate of carcinogens and its transportation in the liver through Chemicalbook to achieve the effect of cancer prevention and anticancer. Chlorogenic acid has a significant inhibitory effect on colorectal cancer, liver cancer and laryngeal cancer, and is considered to be an effective chemical protection agent for cancer.
4)On the cardiovascular protection effect.
Chlorogenic acid as a free radical scavenger and antioxidant has been proved by a large number of experiments, this biological activity of chlorogenic acid, can have a protective effect on the cardiovascular system. Chlorogenic acid Chemicalbook can protect vascular endothelial cells by scavenging free radicals and anti-lipid peroxidation, and then play a role in the prevention and treatment of atherosclerosis, thromboembolic diseases and hypertension.
5)Cholesterol-lowering effect.
The serum total cholesterol of the rats was significantly lower than that of the control group, indicating that Eucommia had an inhibitory effect on cholesterol absorption.
6)Effect of osteocyte proliferation.
The results showed that the water extract of Eutmoia ulmoia and different extracts of the water extract were cultured together with UMR106 osteoblast cells in vitro. The results showed that the water extract had the strongest effect on promoting the proliferation of Chemicalbook cells when cultured at 0.4 g/L for 48 hours, and the ethyl acetate extract and n-butanol extract had a certain effect on cell proliferation. The remaining water layer after extraction still retains the same effect of promoting cell proliferation as the original water layer.
7)Immunomodulation.
The leaf extract of Eucommia ulmoides can increase the spleen weight, the synthesis of RNA and protein in spleen tissue, increase the activity of natural killer cells in blood, and accelerate the proliferation of spleen lymphocytes, but has no obvious effect on spleen antibody forming cells in normal mice.
8)Sex hormones and sex-promoting hormone-like effects.
Eucommia ulmoides extract can increase the weight of prostate, ovary, testis, and levator muscle in animals.
Product Application
1）Pharmaceutical injections, etc.
Preparation for the treatment of cardiovascular and cerebrovascular diseases, myocarditis,
2) Food supplements.
Improve immunity, protect the liver, and help to maintain cardiovascular health.
Preparation for the treatment of cardiovascular and cerebrovascular diseases, myocarditis,
2) Food supplements.
Improve immunity, protect the liver, and help to maintain cardiovascular health.
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Product Data Sheets
| Analysis | Description | Result |
| Purity （HPLC） | Cycloastragenol≥98% | 99.76% |
| Appearance | Off white powder to white powder | Conforms |
| Particle-size | NLT100% 80 mesh | Conforms |
| Loss on drying | ≤1.0% | 0.56% |
| Lead | ≤0.1mg/kg | Conforms |
| As | ≤0.1mg/kg | Conforms |
| Mercury | ≤0.01mg/kg | Conforms |
| Cadmium | ≤0.5 mg/kg | Conforms |
| Total number of bacteria | ≤1000cfu/g | Conforms |
| Yeast | ≤100cfu/g | Conforms |
| Escherichia coli | Not included | Not detected |
| Salmonella | Not included | Not detected |
| Staphylococcus | Not included | Not detected |